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TP53 N235S - Gene Variant Detail

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Gene TP53
Variant N235S
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions TP53 N235S lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). N235S results in colony growth, induction of apoptosis, and transcriptional activity similar to wild-type Tp53 in cultured cells (PMID: 33257846) and in a reporter assay (PMID: 39140857), and therefore, is predicted to have no effect on Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 N235S

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Transcript NM_000546.6
gDNA chr17:g.7674259T>C
cDNA c.704A>G
Protein p.N235S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.7674259T>C c.704A>G p.N235S RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674259T>C c.704A>G p.N235S RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674259T>C c.704A>G p.N235S RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674259T>C c.704A>G p.N235S RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674259T>C c.704A>G p.N235S RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674259T>C c.704A>G p.N235S RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674259T>C c.704A>G p.N235S RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674259T>C c.704A>G p.N235S RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674259T>C c.704A>G p.N235S RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674259T>C c.704A>G p.N235S RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674259T>C c.704A>G p.N235S RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674259T>C c.704A>G p.N235S RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674259T>C c.704A>G p.N235S RefSeq GRCh38/hg38

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Molecular Profile Protein Effect Treatment Approaches
TP53 N235S no effect - predicted