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Gene | TP53 |
Variant | N235S |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | TP53 N235S lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). N235S results in colony growth, induction of apoptosis, and transcriptional activity similar to wild-type Tp53 in cultured cells (PMID: 33257846) and in a reporter assay (PMID: 39140857), and therefore, is predicted to have no effect on Tp53 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon7 TP53 N235S |
Transcript | NM_000546.6 |
gDNA | chr17:g.7674259T>C |
cDNA | c.704A>G |
Protein | p.N235S |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |