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Gene | TP53 |
Variant | S366A |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | TP53 S366A lies within the HIPK1 and CARM1-interacting regions of the Tp53 protein (UniProt.org). S366A results in colony growth (PMID: 33257846), p21 binding, regulation of target promoters, and STAT4 activation similar to wild-type Tp53 in culture (PMID: 24076587), and therefore, is predicted to have no effect on Tp53 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon10 TP53 S366A |
Transcript | NM_000546.6 |
gDNA | chr17:g.7670613A>C |
cDNA | c.1096T>G |
Protein | p.S366A |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001126112.3 | chr17:g.7670613A>C | c.1096T>G | p.S366A | RefSeq | GRCh38/hg38 |
NM_000546.5 | chr17:g.7670613A>C | c.1096T>G | p.S366A | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7670613A>C | c.1096T>G | p.S366A | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7670613A>C | c.1096T>G | p.S366A | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7670613A>C | c.1096T>G | p.S366A | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7670613A>C | c.1096T>G | p.S366A | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7670613A>C | c.1096T>G | p.S366A | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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