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Gene TP53
Variant G360V
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions TP53 G360V lies within the CARM1, HIPK1, HIPK2, and USP7-interacting regions of the Tp53 protein (UniProt.org). G360V results in colony growth similar to wild-type Tp53 (PMID: 33257846), but demonstrates increased transactivation of Tp53 response elements, decreased colony growth, and increased apoptosis in cultured cells in another study (PMID: 27297285), and therefore, is predicted to lead to a gain of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 act mut TP53 G360V

TP53 mutant TP53 exon10 TP53 G360V

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Transcript NM_000546.6
gDNA chr17:g.7670630C>A
cDNA c.1079G>T
Protein p.G360V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407266.1 chr17:g.7670630C>A c.1079G>T p.G360V RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670630C>A c.1079G>T p.G360V RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670630C>A c.1079G>T p.G360V RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670630C>A c.1079G>T p.G360V RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670630C>A c.1079G>T p.G360V RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7670630C>A c.1079G>T p.G360V RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7670630C>A c.1079G>T p.G360V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References