Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | TP53 |
Variant | E358V |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | TP53 E358V lies within the HIPK1, HIPK2, and CARM1-interacting region of the Tp53 protein (UniProt.org). E358V results in colony growth, induction of apoptosis, and transcriptional activity similar to wild-type Tp53 in cultured cells (PMID: 33257846), and therefore, is predicted to have no effect on Tp53 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon10 TP53 E358V |
Transcript | NM_000546.6 |
gDNA | chr17:g.7670636T>A |
cDNA | c.1073A>T |
Protein | p.E358V |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001126112.2 | chr17:g.7670636T>A | c.1073A>T | p.E358V | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7670636T>A | c.1073A>T | p.E358V | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7670636T>A | c.1073A>T | p.E358V | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7670636T>A | c.1073A>T | p.E358V | RefSeq | GRCh38/hg38 |
NM_000546.5 | chr17:g.7670636T>A | c.1073A>T | p.E358V | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7670636T>A | c.1073A>T | p.E358V | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7670636T>A | c.1073A>T | p.E358V | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|