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Gene | TP53 |
Variant | R156H |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 R156H lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). R156H results in induction of apoptosis similar to wild-type in Tp53-null cells in culture (PMID: 30840781), transcriptional activity in yeast, and suppression of colony growth in human cells similar to wild-type Tp53, however, demonstrates decreased Tp53 protein expression and p21 induction in human cells (PMID: 10435620), and therefore, its effect on Tp53 protein function is unknown. |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon5 TP53 R156H |
Transcript | NM_000546.6 |
gDNA | chr17:g.7675145C>T |
cDNA | c.467G>A |
Protein | p.R156H |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |