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Gene TP53
Variant P222L
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions TP53 P222L lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). P222L results in colony growth and transcriptional activity similar to wild-type Tp53 in cultured cells (PMID: 33257846), and therefore, is predicted to have no effect on Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 P222L

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Transcript NM_000546.6
gDNA chr17:g.7674866G>A
cDNA c.665C>T
Protein p.P222L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407266.1 chr17:g.7674866G>A c.665C>T p.P222L RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674866G>A c.665C>T p.P222L RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674866G>A c.665C>T p.P222L RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674866G>A c.665C>T p.P222L RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674866G>A c.665C>T p.P222L RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674866G>A c.665C>T p.P222L RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674866G>A c.665C>T p.P222L RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674866G>A c.665C>T p.P222L RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674866G>A c.665C>T p.P222L RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674866G>A c.665C>T p.P222L RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674866G>A c.665C>T p.P222L RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674866G>A c.665C>T p.P222L RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674866G>A c.665C>T p.P222L RefSeq GRCh38/hg38

Filtering

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References