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Gene DNMT3A
Variant P777R
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions DNMT3A P777R lies within the SAM-dependent MTase C5-type domain of the Dnmt3a protein (UniProt.org). P777R (corresponds to P773R in mouse) retains DNA-binding ability but results in decreased methylation activity in in vitro assays (PMID: 31861499), and therefore, is predicted to lead to a loss of Dnmt3a protein function.
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A inact mut DNMT3A P777R

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Transcript NM_022552.5
gDNA chr2:g.25239208G>C
cDNA c.2330C>G
Protein p.P777R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017003526.1 chr2:g.25239208G>C c.2330C>G p.P777R RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25239208G>C c.2330C>G p.P777R RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25239208G>C c.2330C>G p.P777R RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25239208G>C c.2330C>G p.P777R RefSeq GRCh38/hg38
XM_047443593.1 chr2:g.25239208G>C c.2330C>G p.P777R RefSeq GRCh38/hg38
NM_022552.4 chr2:g.25239208G>C c.2330C>G p.P777R RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25239208G>C c.2330C>G p.P777R RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.25239208G>C c.2330C>G p.P777R RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25239208G>C c.2330C>G p.P777R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries