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Gene FGFR2
Variant L618F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 L618F (corresponds to L617F in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). L618F in combination with FGFR2 H167_N173del results in constitutive FGFR2 signaling in culture (PMID: 33926920), and has been shown to be associated with secondary resistance to FGFR inhibitors (PMID: 33926920, PMID: 37843855), but has not been individually characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 L618F

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Transcript NM_022970.4
gDNA chr10:g.121496544C>A
cDNA c.1854G>T
Protein p.L618F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144913.1 chr10:g.121496544C>A c.1854G>T p.L618F RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121496544C>A c.1854G>T p.L618F RefSeq GRCh38/hg38
XM_017015925.3 chr10:g.121485442_121485444delCTGinsTTT c.1852_1854delCTGinsTTT p.L618F RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121496544C>A c.1854G>T p.L618F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
FGFR2 L618F unknown
FGFR2 H167_N173del FGFR2 L618F
BRAF L597Q FGFR2 H167_N173del FGFR2 L618F
BRAF L597Q FGFR2 H167_N173del FGFR2 N550K FGFR2 L618F NRAS Q61K