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Gene FGFR2
Variant L618F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 L618F (corresponds to L617F in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). L618F in combination with FGFR2 H167_N173del results in constitutive FGFR2 signaling in culture (PMID: 33926920), and has been shown to be associated with secondary resistance to FGFR inhibitors (PMID: 33926920, PMID: 37843855), but has not been individually characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 L618F

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Transcript NM_022970.4
gDNA chr10:g.121496544C>A
cDNA c.1854G>T
Protein p.L618F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017015925.3 chr10:g.121485442_121485444delCTGinsTTT c.1852_1854delCTGinsTTT p.L618F RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121496544C>A c.1854G>T p.L618F RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121496544C>A c.1854G>T p.L618F RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121496544C>A c.1854G>T p.L618F RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References