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Gene PTEN
Variant F90S
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions PTEN F90S lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). F90S demonstrates phosphatase activity comparable to wild-type Pten however, F90S results in reduced membrane localization of the Pten protein due to impaired binding with membrane lipids (PMID: 25448479, PMID: 25263454) and subsequently, is unable to prevent Akt signaling, cell proliferation, and cell migration and therefore, confers a loss of function to the Pten protein (PMID: 25263454).
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN F90S

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Transcript NM_000314.8
gDNA chr10:g.87933028T>C
cDNA c.269T>C
Protein p.F90S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.87933028T>C c.269T>C p.F90S RefSeq GRCh38/hg38
NM_000314 chr10:g.87933028T>C c.269T>C p.F90S RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87933028T>C c.269T>C p.F90S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References