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Gene | NRAS |
Variant | Q61K |
Impact List | missense |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | NRAS Q61K is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). Q61K results in activation of downstream pathway signaling, increased survival, and transformation of cultured cells (PMID: 22718121, PMID: 34117033, PMID: 33431353), and is predicted to lead to a loss of Nras protein function based on the effects of HRAS Q61K (PMID: 3510078). |
Associated Drug Resistance | |
Category Variants Paths |
NRAS mutant NRAS act mut NRAS Q61K NRAS mutant NRAS exon3 NRAS Q61X NRAS Q61K |
Transcript | NM_002524.5 |
gDNA | chr1:g.114713909G>T |
cDNA | c.181C>A |
Protein | p.Q61K |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_002524 | chr1:g.114713909G>T | c.181C>A | p.Q61K | RefSeq | GRCh38/hg38 |
NM_002524.5 | chr1:g.114713909G>T | c.181C>A | p.Q61K | RefSeq | GRCh38/hg38 |
NM_002524.4 | chr1:g.114713909G>T | c.181C>A | p.Q61K | RefSeq | GRCh38/hg38 |