PTEN N340fs
Gene Variant Detail

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Gene PTEN
Variant N340fs
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions PTEN N340fs results in a change in the amino acid sequence of the Pten protein beginning at aa 340 of 403, likely resulting in premature truncation of the functional protein (UniProt.org). N340fs has not been characterized in the scientific literature and therefore, its effect on Pten protein function is unknown (PubMed, Mar 2026).
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN N340fs

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Transcript NM_000314.8
gDNA chr10:g.(87961109_87961110)
cDNA c.(1018_1017)
Protein p.N340fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.8 chr10:g.(87961109_87961110) c.(1018_1017) p.N340fs RefSeq GRCh38/hg38
NM_000314.6 chr10:g.(87961109_87961110) c.(1018_1017) p.N340fs RefSeq GRCh38/hg38
NM_000314 chr10:g.(87961109_87961110) c.(1018_1017) p.N340fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References