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Gene ROS1
Variant R360I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 R360I lies within the extracellular domain of the Ros1 protein (UniProt.org). R360I has been identified in sequencing studies (PMID: 22895193), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 R360I

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Transcript NM_002944.3
gDNA chr6:g.117394247C>A
cDNA c.1079G>T
Protein p.R360I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.2 chr6:g.117394247C>A c.1079G>T p.R360I RefSeq GRCh38/hg38
XM_017011173 chr6:g.117394247C>A c.1079G>T p.R360I RefSeq GRCh38/hg38
XM_011536051.2 chr6:g.117394247C>A c.1079G>T p.R360I RefSeq GRCh38/hg38
XM_017011172.1 chr6:g.117394247C>A c.1079G>T p.R360I RefSeq GRCh38/hg38
XM_017011172.2 chr6:g.117394247C>A c.1079G>T p.R360I RefSeq GRCh38/hg38
XM_017011173.2 chr6:g.117394247C>A c.1079G>T p.R360I RefSeq GRCh38/hg38
XM_011536051.3 chr6:g.117394247C>A c.1079G>T p.R360I RefSeq GRCh38/hg38
XM_017011172 chr6:g.117394247C>A c.1079G>T p.R360I RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117394247C>A c.1079G>T p.R360I RefSeq GRCh38/hg38
XM_011536051 chr6:g.117394247C>A c.1079G>T p.R360I RefSeq GRCh38/hg38
NM_002944 chr6:g.117394247C>A c.1079G>T p.R360I RefSeq GRCh38/hg38
XM_017011173.1 chr6:g.117394247C>A c.1079G>T p.R360I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References