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Gene | ROS1 |
Variant | W1817* |
Impact List | nonsense |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | ROS1 W1817* results in a premature truncation of the Ros1 protein at amino acid 1817 of 2347 (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), W1817* is predicted to lead to a loss of Ros1 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
ROS1 mutant ROS1 inact mut ROS1 W1817* |
Transcript | NM_002944.3 |
gDNA | chr6:g.117326331C>T |
cDNA | c.5450G>A |
Protein | p.W1817* |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_002944 | chr6:g.117326331C>T | c.5450G>A | p.W1817* | RefSeq | GRCh38/hg38 |
NM_002944.3 | chr6:g.117326331C>T | c.5450G>A | p.W1817* | RefSeq | GRCh38/hg38 |
NM_002944.2 | chr6:g.117326331C>T | c.5450G>A | p.W1817* | RefSeq | GRCh38/hg38 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
ROS1 W1817* | loss of function - predicted |