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Gene ROS1
Variant W21*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions ROS1 W21* results in a premature truncation of the Ros1 protein at amino acid 21 of 2347 (UniProt.org). Due to the loss of all known functional domains (UniProt.org), W21* is predicted to lead to a loss of Ros1 protein function.
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 inact mut ROS1 W21*

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Transcript NM_002944.3
gDNA chr6:g.117425595C>T
cDNA c.62G>A
Protein p.W21*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011536053 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536049 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_017011173.1 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536050.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536056.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536054.3 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536057.3 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_017011172.1 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536052.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536050.3 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536055 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536055.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536053.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536058 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536056 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536057 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536054 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536055.3 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536051.3 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_017011173 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536058.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536056.3 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536050 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_006715548.5 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_017011172 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_006715548 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536057.4 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536049.3 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_017011172.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_006715548.4 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536053.3 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536051 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
NM_002944 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_017011173.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536049.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_047419231.1 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536051.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
NM_001378891.1 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536058.3 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
NM_001378902.1 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536054.2 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_011536052 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38
XM_047419232.1 chr6:g.117425595C>T c.62G>A p.W21* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ROS1 W21* loss of function - predicted