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Gene | ROS1 |
Variant | W21* |
Impact List | nonsense |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | ROS1 W21* results in a premature truncation of the Ros1 protein at amino acid 21 of 2347 (UniProt.org). Due to the loss of all known functional domains (UniProt.org), W21* is predicted to lead to a loss of Ros1 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
ROS1 mutant ROS1 inact mut ROS1 W21* |
Transcript | NM_002944.3 |
gDNA | chr6:g.117425595C>T |
cDNA | c.62G>A |
Protein | p.W21* |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_011536053.2 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536053.3 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536053 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536051.3 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_047419232.1 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
NM_001378902.1 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536057.3 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536055 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
NM_002944.2 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536058.3 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536054 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536057 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
NM_001378891.1 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_006715548 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536050.3 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_017011173 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536056 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536052 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536049 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536057.4 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536049.3 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536056.3 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536049.2 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536050 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
NM_002944 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536058 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536052.2 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_017011173.2 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
NM_002944.3 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536050.2 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536051 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_017011172.1 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536051.2 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_006715548.5 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536055.3 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_047419231.1 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536054.3 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_017011172.2 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_017011173.1 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_017011172 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_006715548.4 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536055.2 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536056.2 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536058.2 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
XM_011536054.2 | chr6:g.117425595C>T | c.62G>A | p.W21* | RefSeq | GRCh38/hg38 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
ROS1 W21* | loss of function - predicted |