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Gene ROS1
Variant D780Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 D780Y lies within the extracellular domain of the Ros1 protein (UniProt.org). D780Y has been identified in sequencing studies (PMID: 28069802), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 D780Y

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Transcript NM_002944.3
gDNA chr6:g.117383475C>A
cDNA c.2338G>T
Protein p.D780Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.3 chr6:g.117383475C>A c.2338G>T p.D780Y RefSeq GRCh38/hg38
XM_011536051.2 chr6:g.117383475C>A c.2338G>T p.D780Y RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117383475C>A c.2338G>T p.D780Y RefSeq GRCh38/hg38
XM_011536051 chr6:g.117383475C>A c.2338G>T p.D780Y RefSeq GRCh38/hg38
NM_002944 chr6:g.117383475C>A c.2338G>T p.D780Y RefSeq GRCh38/hg38
XM_011536051.3 chr6:g.117383475C>A c.2338G>T p.D780Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References