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Gene ROS1
Variant E1244*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions ROS1 E1244* results in a premature truncation of the Ros1 protein at amino acid 1244 of 2347 (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), E1244* is predicted to lead to a loss of Ros1 protein function.
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 inact mut ROS1 E1244*

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Transcript NM_002944.3
gDNA chr6:g.117357928C>A
cDNA c.3730G>T
Protein p.E1244*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.3 chr6:g.117357928C>A c.3730G>T p.E1244* RefSeq GRCh38/hg38
XM_017011172.1 chr6:g.117357889C>A c.3730G>T p.E1244* RefSeq GRCh38/hg38
XM_017011172 chr6:g.117357889C>A c.3730G>T p.E1244* RefSeq GRCh38/hg38
NM_002944 chr6:g.117357928C>A c.3730G>T p.E1244* RefSeq GRCh38/hg38
XM_017011172.2 chr6:g.117357889C>A c.3730G>T p.E1244* RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117357928C>A c.3730G>T p.E1244* RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References