FBXW7 W406R
Gene Variant Detail

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Gene FBXW7
Variant W406R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FBXW7 W406R lies within WD repeat 1 of the Fbxw7 protein (UniProt.org). W406C retains the ability to bind and degrade NICD (PMID: 27247421, PMID: 32907612), Myc, Mcl-1, Braf, and Cyclin E (PMID: 32907612), binds to the large T antigen of Merkel cell polyomavirus similar to wild-type Fbxw7, and demonstrates increased binding to small T antigen in culture (PMID: 32427880), but results in decreased inhibition of Notch transcriptional activity in a reporter assay (PMID: 27247421), and therefore, its effect on Fbxw7 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 W406R

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Transcript NM_001349798.2
gDNA chr4:g.152329692A>T
cDNA c.1216T>A
Protein p.W406R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_024454123.1 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
NM_018315.5 chr4:g.152326194A>T c.1216T>A p.W406R RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152329692A>T c.1216T>A p.W406R RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References