KDR R1032Q
Gene Variant Detail

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Gene KDR
Variant R1032Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions KDR (VEGFR2) R1032Q lies within the protein kinase domain of the Kdr (Vegfr2) protein (UniProt.org). R1032Q results in decreased ligand-induced phosphorylation of Kdr (Vegfr2) and Mapk in cell culture (PMID: 28743916), but demonstrates increased phosphorylation of Erk, Akt and p85 leading to altered extracellular matrix architecture in culture in a different study (PMID: 41535257), and induces tumor growth in mouse models above wild-type protein (PMID: 29588308, PMID: 41535257), and therefore, its effect on Kdr (Vegfr2) protein function is unknown.
Associated Drug Resistance
Category Variants Paths

KDR mutant KDR R1032Q

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Transcript NM_002253.4
gDNA chr4:g.55090053C>T
cDNA c.3095G>A
Protein p.R1032Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002253 chr4:g.55090053C>T c.3095G>A p.R1032Q RefSeq GRCh38/hg38
NM_002253.3 chr4:g.55090053C>T c.3095G>A p.R1032Q RefSeq GRCh38/hg38
NM_002253.4 chr4:g.55090053C>T c.3095G>A p.R1032Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
KDR R1032Q unknown