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Gene FGFR1
Variant A21T
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR1 A21T lies within the signal peptide region of the Fgfr1 protein (UniProt.org). A21T results in transformation activity similar to wild-type Fgfr1 in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 A21T

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Transcript NM_023110.3
gDNA chr8:g.38457386C>T
cDNA c.61G>A
Protein p.A21T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006716304.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_023105.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_006716314.3 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_006716311.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_047421569.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001354368.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_017013225.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001174063.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_006716312.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_023106.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_006716312.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001174065.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_006716310.3 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001354370.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_006716314.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_006716311.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001174066.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001354370.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001174064.2 chr8:g.38440312C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001174063.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_047421574.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001410922.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_023105.3 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_047421573.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_006716307.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_006716310.4 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001354367.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_023106.3 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001174066.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_015850.3 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_017013224.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001354367.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001354368.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_017013222.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001354369.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_015850.4 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_047421570.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_017013225.3 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_006716307.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_024447097.1 chr8:g.38440312C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001174065.2 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
NM_001354369.1 chr8:g.38457386C>T c.61G>A p.A21T RefSeq GRCh38/hg38
XM_011544451.1 chr8:g.38440312C>T c.61G>A p.A21T RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 A21T Advanced Solid Tumor predicted - sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A21T were sensitive to treatment with AZD4547 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 A21T Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A21T were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 A21T Advanced Solid Tumor predicted - sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A21T were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 A21T Advanced Solid Tumor predicted - sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A21T were sensitive to treatment with Lytgobi (futibatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 A21T Advanced Solid Tumor predicted - sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A21T were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 A21T Advanced Solid Tumor predicted - sensitive E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A21T were sensitive to treatment with E7090 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467