Gene Variant Detail

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Gene FGFR1
Variant S436F
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR1 S436F lies within the cytoplasmic domain of the Fgfr1 protein (UniProt.org). S436F results in proliferation similar to wild-type in a competition assay but decreased transformation activity in cultured cells (PMID: 34272467), and therefore, is predicted to lead to a loss of Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 inact mut FGFR1 S436F

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Transcript NM_023110.3
gDNA chr8:g.38418351G>A
cDNA c.1307C>T
Protein p.S436F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_023110.2 chr8:g.38418351G>A c.1307C>T p.S436F RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38418351G>A c.1307C>T p.S436F RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38418351G>A c.1307C>T p.S436F RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38418351G>A c.1307C>T p.S436F RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38418351G>A c.1307C>T p.S436F RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38418351G>A c.1307C>T p.S436F RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38418351G>A c.1307C>T p.S436F RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38418351G>A c.1307C>T p.S436F RefSeq GRCh38/hg38

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  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 S436F Advanced Solid Tumor predicted - sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 S436F were sensitive to treatment with AZD4547 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 S436F Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 S436F were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 S436F Advanced Solid Tumor predicted - resistant E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 S436F were resistant to treatment with E7090 in culture (PMID: 34272467). 34272467
FGFR1 S436F Advanced Solid Tumor predicted - sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 S436F were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 S436F Advanced Solid Tumor predicted - sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 S436F were sensitive to treatment with Lytgobi (futibatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 S436F Advanced Solid Tumor predicted - sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 S436F were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467