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Gene FGFR1
Variant T319A
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR1 T319A lies within Ig-like C2-type domain 3 of the Fgfr1 protein (UniProt.org). T319A results in decreased proliferation relative to wild-type Fgfr1 in a competition assay and decreased transformation activity in cultured cells (PMID: 34272467), and therefore, is predicted to lead to a loss of Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 inact mut FGFR1 T319A

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Transcript NM_023110.3
gDNA chr8:g.38421923T>C
cDNA c.955A>G
Protein p.T319A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_023110.2 chr8:g.38421923T>C c.955A>G p.T319A RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38421923T>C c.955A>G p.T319A RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38421923T>C c.955A>G p.T319A RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38421923T>C c.955A>G p.T319A RefSeq GRCh38/hg38
NM_001174063.1 chr8:g.38421923T>C c.955A>G p.T319A RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38421923T>C c.955A>G p.T319A RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38421923T>C c.955A>G p.T319A RefSeq GRCh38/hg38
NM_001174063.2 chr8:g.38421923T>C c.955A>G p.T319A RefSeq GRCh38/hg38
XM_047421570.1 chr8:g.38421923T>C c.955A>G p.T319A RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38421923T>C c.955A>G p.T319A RefSeq GRCh38/hg38
XM_017013222.2 chr8:g.38421923T>C c.955A>G p.T319A RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38421923T>C c.955A>G p.T319A RefSeq GRCh38/hg38

Filtering

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries