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Gene FGFR1
Variant A121D
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR1 A121D lies within the extracellular domain of the Fgfr1 protein (UniProt.org). A121D results in transformation activity similar to wild-type Fgfr1 in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 A121D

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Transcript NM_023110.3
gDNA chr8:g.38428432G>T
cDNA c.362C>A
Protein p.A121D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017013225.2 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
NM_001174063.1 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
NM_001174063.2 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
NM_015850.3 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
XM_017013225.3 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
NM_001354369.1 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
XM_006716307.1 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
NM_001174065.2 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
NM_001354367.1 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
XM_047421569.1 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
XM_017013222.2 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
NM_001174065.1 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
NM_001410922.1 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
XM_047421570.1 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
XM_017013224.2 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
NM_015850.4 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
XM_006716307.2 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
NM_001354367.2 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
NM_001354369.2 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38428432G>T c.362C>A p.A121D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 A121D Advanced Solid Tumor predicted - sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A121D were sensitive to treatment with AZD4547 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 A121D Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A121D were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 A121D Advanced Solid Tumor predicted - resistant Dovitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A121D were resistant to treatment with Dovitinib (TKI258) in culture (PMID: 34272467). 34272467
FGFR1 A121D Advanced Solid Tumor predicted - sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A121D were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 A121D Advanced Solid Tumor predicted - sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A121D were sensitive to treatment with Lytgobi (futibatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 A121D Advanced Solid Tumor predicted - sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A121D were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 A121D Advanced Solid Tumor predicted - sensitive E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A121D were sensitive to treatment with E7090 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467