FGFR1 R445W
Gene Variant Detail

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Gene FGFR1
Variant R445W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 R445W lies within the cytoplasmic domain of the Fgfr1 protein (UniProt.org). R445W results in decreased proliferation relative to wild-type Fgfr1 in a competition assay but transformation activity similar to wild-type Fgfr1 in culture (PMID: 34272467), and therefore, its effect on Fgfr1 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 R445W

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Transcript NM_023110.3
gDNA chr8:g.38418325G>A
cDNA c.1333C>T
Protein p.R445W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006716304.1 chr8:g.38418325G>A c.1333C>T p.R445W RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38418325G>A c.1333C>T p.R445W RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38418325G>A c.1333C>T p.R445W RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38418325G>A c.1333C>T p.R445W RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38418325G>A c.1333C>T p.R445W RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38418325G>A c.1333C>T p.R445W RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38418325G>A c.1333C>T p.R445W RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38418325G>A c.1333C>T p.R445W RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 R445W Advanced Solid Tumor predicted - sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 R445W were sensitive to treatment with Fexagratinib (AZD4547) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 R445W Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 R445W were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 R445W Advanced Solid Tumor predicted - sensitive E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 R445W were sensitive to treatment with E7090 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 R445W Advanced Solid Tumor predicted - sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 R445W were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 R445W Advanced Solid Tumor predicted - sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 R445W were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467