Gene Variant Detail

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Gene FGFR1
Variant S588T
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR1 S588T lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). S588T results in transformation activity similar to wild-type Fgfr1 in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 S588T

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Transcript NM_023110.3
gDNA chr8:g.38415961C>G
cDNA c.1763G>C
Protein p.S588T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006716304.1 chr8:g.38415961C>G c.1763G>C p.S588T RefSeq GRCh38/hg38
XM_024447097.1 chr8:g.38415938A>T c.1762T>A p.S588T RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38415961C>G c.1763G>C p.S588T RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38415961C>G c.1763G>C p.S588T RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38415961C>G c.1763G>C p.S588T RefSeq GRCh38/hg38
NM_001354368.2 chr8:g.38414565C>G c.1763G>C p.S588T RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38415961C>G c.1763G>C p.S588T RefSeq GRCh38/hg38
XM_011544451.1 chr8:g.38414285A>T c.1762T>A p.S588T RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38415961C>G c.1763G>C p.S588T RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38415961C>G c.1763G>C p.S588T RefSeq GRCh38/hg38
XM_047421574.1 chr8:g.38414565C>G c.1763G>C p.S588T RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38415961C>G c.1763G>C p.S588T RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 S588T Advanced Solid Tumor predicted - sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 S588T were sensitive to treatment with AZD4547 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 S588T Advanced Solid Tumor predicted - sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 S588T were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 S588T Advanced Solid Tumor predicted - sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 S588T were sensitive to treatment with Lytgobi (futibatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 S588T Advanced Solid Tumor predicted - sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 S588T were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 S588T Advanced Solid Tumor predicted - sensitive E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 S588T were sensitive to treatment with E7090 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467