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Gene FGFR1
Variant G703S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 G703S lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). G703S results in decreased proliferation relative to wild-type Fgfr1 in a competition assay but transformation activity similar to wild-type Fgfr1 (PMID: 34272467), and therefore, its effect on Fgfr1 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 G703S

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Transcript NM_023110.3
gDNA chr8:g.38414231C>T
cDNA c.2107G>A
Protein p.G703S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006716304.1 chr8:g.38414231C>T c.2107G>A p.G703S RefSeq GRCh38/hg38
XM_006716312.2 chr8:g.38412512_38412514delGGGinsAGC c.2107_2109delGGGinsAGC p.G703S RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38414231C>T c.2107G>A p.G703S RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38414231C>T c.2107G>A p.G703S RefSeq GRCh38/hg38
XM_006716310.4 chr8:g.38412512_38412514delGGGinsAGC c.2107_2109delGGGinsAGC p.G703S RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38414231C>T c.2107G>A p.G703S RefSeq GRCh38/hg38
XM_006716311.1 chr8:g.38412512_38412514delGGGinsAGC c.2107_2109delGGGinsAGC p.G703S RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38414231C>T c.2107G>A p.G703S RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38414231C>T c.2107G>A p.G703S RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38414231C>T c.2107G>A p.G703S RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38414231C>T c.2107G>A p.G703S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
FGFR1 G703S unknown