Gene Variant Detail

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Gene FGFR1
Variant R809Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 R809Q lies within the cytoplasmic domain of the Fgfr1 protein (UniProt.org). R809Q results in decreased proliferation relative to wild-type Fgfr1 in a competition assay but transformation activity similar to wild-type Fgfr1 in culture (PMID: 34272467), and therefore, its effect on Fgfr1 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 R809Q

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Transcript NM_023110.3
gDNA chr8:g.38413671C>T
cDNA c.2426G>A
Protein p.R809Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_023110.2 chr8:g.38413671C>T c.2426G>A p.R809Q RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38413671C>T c.2426G>A p.R809Q RefSeq GRCh38/hg38
XM_011544445.3 chr8:g.38412554_38412555delGCinsAA c.2426_2427delGCinsAA p.R809Q RefSeq GRCh38/hg38
XM_011544444.2 chr8:g.38412554_38412555delGCinsAA c.2426_2427delGCinsAA p.R809Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FGFR1 R809Q unknown