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Gene FGFR2
Variant L550F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 L550F lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). L550F has been demonstrated to confer resistance to Fgfr inhibitors as a secondary resistance mutation (PMID: 34250419), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 L550F

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Transcript NM_000141.5
gDNA chr10:g.121498519G>A
cDNA c.1648C>T
Protein p.L550F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.4 chr10:g.121498519G>A c.1648C>T p.L550F RefSeq GRCh38/hg38
NM_001144916.1 chr10:g.121487418G>A c.1648C>T p.L550F RefSeq GRCh38/hg38
NM_001144916.2 chr10:g.121487418G>A c.1648C>T p.L550F RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121498519G>A c.1648C>T p.L550F RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References