FGFR2 N652S
Gene Variant Detail

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Gene FGFR2
Variant N652S
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 N652S lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). N652S results in growth factor-independent growth in a high-throughput cell culture assay (PMID: 41361008), and has been demonstrated to confer resistance to Fgfr inhibitors as a secondary resistance mutation (PMID: 34250419), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 N652S

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Transcript NM_000141.5
gDNA chr10:g.121488022T>C
cDNA c.1955A>G
Protein p.N652S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.121488022T>C c.1955A>G p.N652S RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121488022T>C c.1955A>G p.N652S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Protein Effect Treatment Approaches
FGFR2 N652S gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor