FGFR2 K659Q
Gene Variant Detail

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Gene FGFR2
Variant K659Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 K659Q lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K659Q has been demonstrated to confer resistance to Fgfr inhibitors as a secondary resistance mutation (PMID: 34250419), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Dec 2025).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 K659Q

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Transcript NM_000141.5
gDNA chr10:g.121488002T>G
cDNA c.1975A>C
Protein p.K659Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017015920.2 chr10:g.121488056T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121488005T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121488002T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121488002T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121488005T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121488005T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
XM_017015920.3 chr10:g.121488056T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121488005T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
XM_006717708.4 chr10:g.121488056T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
XM_006717708.3 chr10:g.121488056T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References