FGFR2 K659Q
Gene Variant Detail

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Gene FGFR2
Variant K659Q
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 K659Q lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K659Q results in growth factor-independent growth in a high-throughput cell culture assay (PMID: 41361008), and has been demonstrated to confer resistance to Fgfr inhibitors as a secondary resistance mutation (PMID: 34250419), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 K659Q

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Transcript NM_000141.5
gDNA chr10:g.121488002T>G
cDNA c.1975A>C
Protein p.K659Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.121488002T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121488005T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
XM_006717708.4 chr10:g.121488056T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
XM_006717708.3 chr10:g.121488056T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121488005T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121488005T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121488002T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
XM_017015920.2 chr10:g.121488056T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121488005T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
XM_017015920.3 chr10:g.121488056T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References