Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene FGFR2
Variant K659Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 K659Q lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K659Q has been demonstrated to confer resistance to Fgfr inhibitors as a secondary resistance mutation (PMID: 34250419), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 K659Q

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_000141.5
gDNA chr10:g.121488002T>G
cDNA c.1975A>C
Protein p.K659Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970.4 chr10:g.121488005T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121488005T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
XM_006717708.4 chr10:g.121488056T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121488002T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
XM_017015920.2 chr10:g.121488056T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121488005T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
XM_017015920.3 chr10:g.121488056T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121488002T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
XM_006717708.3 chr10:g.121488056T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121488005T>G c.1975A>C p.K659Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References