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Gene FGFR2
Variant Q746L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 Q746L lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). Q746L has been demonstrated to confer resistance to Fgfr inhibitors as a secondary resistance mutation (PMID: 34250419), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 Q746L

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Transcript NM_000141.5
gDNA chr10:g.121483762T>A
cDNA c.2237A>T
Protein p.Q746L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.121483762T>A c.2237A>T p.Q746L RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121483762T>A c.2237A>T p.Q746L RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References