Gene Variant Detail

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Gene FGFR3
Variant G66fs
Impact List frameshift
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR3 G66fs results in a change in the amino acid sequence of the Fgfr3 protein beginning at aa 66 of 806, likely resulting in premature truncation of the functional protein (UniProt.org). G66fs results in proliferation similar to wild-type Fgfr3 in a competition assay and transformation activity similar to wild-type Fgfr3 in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr3 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 G66fs

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Transcript NM_000142.5
gDNA chr4:g.(1799339_1799340)
cDNA c.(196_195)
Protein p.G66fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047449822.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_006713871.2 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_006713870.2 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_006713869.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_006713871.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_006713868.2 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_011513422.2 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_011513422.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
NM_001163213.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
NM_001354809.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_047449820.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
NM_001163213.2 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
NM_001354809.2 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
NM_001354810.2 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
NM_022965.4 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_011513420.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_006713870.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_006713869.2 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_011513420.2 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_047449821.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
NM_022965.3 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
NM_000142.5 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
NM_000142.4 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
NM_001354810.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38
XM_006713868.1 chr4:g.(1799339_1799340) c.(196_195) p.G66fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FGFR3 G66fs no effect - predicted