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Gene | FGFR3 |
Variant | A265T |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | FGFR3 A265T lies within Ig-like C2-type domain 3 of the Fgfr3 protein (UniProt.org). A265T results in proliferation similar to wild-type Fgfr3 in a competition assay and transformation activity similar to wild-type Fgfr3 in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr3 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
FGFR3 mutant FGFR3 A265T |
Transcript | NM_000142.5 |
gDNA | chr4:g.1801888G>A |
cDNA | c.793G>A |
Protein | p.A265T |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |