Gene Variant Detail

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Gene FGFR3
Variant K403fs
Impact List frameshift
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR3 K403fs results in a change in the amino acid sequence of the Fgfr3 protein beginning at aa 403 of 806, likely resulting in premature truncation of the functional protein (UniProt.org). K403fs results in proliferation similar to wild-type Fgfr3 in a competition assay and transformation activity similar to wild-type Fgfr3 in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr3 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 K403fs

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Transcript NM_000142.5
gDNA chr4:g.(1804460_1804461)
cDNA c.(1207_1206)
Protein p.K403fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354810.2 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
NM_000142.5 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_011513422.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_011513422.2 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
NM_001354810.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_011513420.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
NM_001354809.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_011513420.2 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
NM_000142.4 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_047449822.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
NM_001354809.2 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FGFR3 K403fs no effect - predicted