Gene Variant Detail

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Gene FGFR3
Variant K403fs
Impact List frameshift
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR3 K403fs results in a change in the amino acid sequence of the Fgfr3 protein beginning at aa 403 of 806, likely resulting in premature truncation of the functional protein (UniProt.org). K403fs results in proliferation similar to wild-type Fgfr3 in a competition assay and transformation activity similar to wild-type Fgfr3 in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr3 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 K403fs

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Transcript NM_000142.5
gDNA chr4:g.(1804460_1804461)
cDNA c.(1207_1206)
Protein p.K403fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011513420.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_011513422.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
NM_001354810.2 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
NM_000142.5 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_011513420.2 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
NM_001354809.2 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
NM_000142.4 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_011513422.2 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_047449822.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
NM_001354810.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38
NM_001354809.1 chr4:g.(1804460_1804461) c.(1207_1206) p.K403fs RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References