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Gene FGFR2
Variant A67V
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 A67V lies within Ig-like C2-type domain 1 of the Fgfr2 protein (UniProt.org). A67V results in decreased proliferation relative to wild-type Fgfr2 in a competition assay but increased transformation activity in cultured cells (PMID: 34272467), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 A67V

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Transcript NM_000141.5
gDNA chr10:g.121565614G>A
cDNA c.200C>T
Protein p.A67V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144913.1 chr10:g.121565614G>A c.200C>T p.A67V RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121565614G>A c.200C>T p.A67V RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121565614G>A c.200C>T p.A67V RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121565614G>A c.200C>T p.A67V RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121565614G>A c.200C>T p.A67V RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121565614G>A c.200C>T p.A67V RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121565614G>A c.200C>T p.A67V RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121565614G>A c.200C>T p.A67V RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121565614G>A c.200C>T p.A67V RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121565614G>A c.200C>T p.A67V RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121565614G>A c.200C>T p.A67V RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121565614G>A c.200C>T p.A67V RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries