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Gene FGFR2
Variant H242Y
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 H242Y lies within Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). H242Y results in proliferation similar to wild-type Fgfr2 in a competition assay and transformation activity similar to wild-type in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 H242Y

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Transcript NM_000141.5
gDNA chr10:g.121538616G>A
cDNA c.724C>T
Protein p.H242Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144917.1 chr10:g.121538616G>A c.724C>T p.H242Y RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121538616G>A c.724C>T p.H242Y RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121538616G>A c.724C>T p.H242Y RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121538616G>A c.724C>T p.H242Y RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121538616G>A c.724C>T p.H242Y RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121538616G>A c.724C>T p.H242Y RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121538616G>A c.724C>T p.H242Y RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121538616G>A c.724C>T p.H242Y RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121538616G>A c.724C>T p.H242Y RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121538616G>A c.724C>T p.H242Y RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121538616G>A c.724C>T p.H242Y RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121538616G>A c.724C>T p.H242Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
FGFR2 H242Y no effect - predicted