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Gene FGFR2
Variant R399*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR2 R399* results in a premature truncation of the Fgfr2 protein at amino acid 399 of 821 (UniProt.org). R399* results in decreased proliferation relative to wild-type Fgfr2 in a competition assay and decreased transformation activity in cultured cells (PMID: 34272467), and therefore, is predicted to lead to a loss of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 inact mut FGFR2 R399*

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Transcript NM_000141.5
gDNA chr10:g.121515209G>A
cDNA c.1195C>T
Protein p.R399*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658.2 chr10:g.121515209G>A c.1195C>T p.R399* RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121515209G>A c.1195C>T p.R399* RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121515209G>A c.1195C>T p.R399* RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515209G>A c.1195C>T p.R399* RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References