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Gene FGFR2
Variant S791T
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 S791T lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). S791T results in proliferation similar to wild-type Fgfr2 in a competition assay but increased transformation activity in cultured cells (PMID: 34272467), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 S791T

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Transcript NM_000141.5
gDNA chr10:g.121479952A>T
cDNA c.2371T>A
Protein p.S791T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.121479952A>T c.2371T>A p.S791T RefSeq GRCh38/hg38
XM_006717708.4 chr10:g.121480005C>G c.2372G>C p.S791T RefSeq GRCh38/hg38
XM_017015920.3 chr10:g.121480097C>G c.2372G>C p.S791T RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121479952A>T c.2371T>A p.S791T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FGFR2 S791T gain of function - predicted