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Gene ROS1
Variant E290*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions ROS1 E290* results in a premature truncation of the Ros1 protein at amino acid 290 of 2347 (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), E290* is predicted to lead to a loss of Ros1 protein function.
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 inact mut ROS1 E290*

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Transcript NM_002944.3
gDNA chr6:g.117394727C>A
cDNA c.868G>T
Protein p.E290*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017011172 chr6:g.117394727C>A c.868G>T p.E290* RefSeq GRCh38/hg38
XM_017011173.2 chr6:g.117394727C>A c.868G>T p.E290* RefSeq GRCh38/hg38
XM_011536051 chr6:g.117394727C>A c.868G>T p.E290* RefSeq GRCh38/hg38
XM_017011173 chr6:g.117394727C>A c.868G>T p.E290* RefSeq GRCh38/hg38
NM_002944 chr6:g.117394727C>A c.868G>T p.E290* RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117394727C>A c.868G>T p.E290* RefSeq GRCh38/hg38
XM_011536051.2 chr6:g.117394727C>A c.868G>T p.E290* RefSeq GRCh38/hg38
XM_017011173.1 chr6:g.117394727C>A c.868G>T p.E290* RefSeq GRCh38/hg38
XM_017011172.2 chr6:g.117394727C>A c.868G>T p.E290* RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117394727C>A c.868G>T p.E290* RefSeq GRCh38/hg38
XM_011536051.3 chr6:g.117394727C>A c.868G>T p.E290* RefSeq GRCh38/hg38
XM_017011172.1 chr6:g.117394727C>A c.868G>T p.E290* RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References