PIK3CA D746V
Gene Variant Detail

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Gene PIK3CA
Variant D746V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA D746V does not lie within any known functional domains of the Pik3ca protein (UniProt.org). D746V has been identified in sequencing studies (PMID: 22653804, PMID: 23765252), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA D746V

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Transcript NM_006218.4
gDNA chr3:g.179224130A>T
cDNA c.2237A>T
Protein p.D746V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.4 chr3:g.179224130A>T c.2237A>T p.D746V RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179224130A>T c.2237A>T p.D746V RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179224130A>T c.2237A>T p.D746V RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179224130A>T c.2237A>T p.D746V RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179224130A>T c.2237A>T p.D746V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References