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Gene TP53
Variant C182S
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions TP53 C182S lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). C182S results in disulfide-dependent binding and induction of p21 expression similar to wild-type Tp53 in cultured cells (PMID: 34679713), and therefore, is predicted to have no effect on Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 C182S

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Transcript NM_000546.6
gDNA chr17:g.7675068A>T
cDNA c.544T>A
Protein p.C182S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407262.1 chr17:g.7675068A>T c.544T>A p.C182S RefSeq GRCh38/hg38
NM_001276698.3 chr17:g.7673312A>T c.544T>A p.C182S RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675068A>T c.544T>A p.C182S RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675068A>T c.544T>A p.C182S RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675068A>T c.544T>A p.C182S RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675068A>T c.544T>A p.C182S RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675068A>T c.544T>A p.C182S RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675068A>T c.544T>A p.C182S RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675068A>T c.544T>A p.C182S RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675068A>T c.544T>A p.C182S RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675068A>T c.544T>A p.C182S RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675068A>T c.544T>A p.C182S RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675068A>T c.544T>A p.C182S RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675068A>T c.544T>A p.C182S RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References