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Gene TP53
Variant C176S
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 C176S lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). C176S is associated with increased protein stability (PMID: 34178628), but results in loss of p21 induction and altered disulfide-dependent complexing in cultured cells (PMID: 34679713), and therefore, is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 C176S

TP53 mutant TP53 inact mut TP53 C176S

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Transcript NM_000546.6
gDNA chr17:g.7675086A>T
cDNA c.526T>A
Protein p.C176S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.2 chr17:g.7675086A>T c.526T>A p.C176S RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675086A>T c.526T>A p.C176S RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675086A>T c.526T>A p.C176S RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675086A>T c.526T>A p.C176S RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675086A>T c.526T>A p.C176S RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675086A>T c.526T>A p.C176S RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675086A>T c.526T>A p.C176S RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675086A>T c.526T>A p.C176S RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675086A>T c.526T>A p.C176S RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675086A>T c.526T>A p.C176S RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675086A>T c.526T>A p.C176S RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675086A>T c.526T>A p.C176S RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675086A>T c.526T>A p.C176S RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References