FGFR2 D650Y
Gene Variant Detail

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Gene FGFR2
Variant D650Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 D650Y lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). D650Y has been demonstrated to confer resistance to Fgfr inhibitors as a secondary resistance mutation (PMID: 34250419), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 D650Y

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Transcript NM_000141.5
gDNA chr10:g.121488029C>A
cDNA c.1948G>T
Protein p.D650Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.121488029C>A c.1948G>T p.D650Y RefSeq GRCh38/hg38
NM_001144919.2 chr10:g.121483787C>A c.1948G>T p.D650Y RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121488029C>A c.1948G>T p.D650Y RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References