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Gene CHEK2
Variant P426H
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CHEK2 P426H lies within the protein kinase domain of the Chek2 protein (UniProt.org). P426H has been identified in sequencing studies (PMID: 32183364), but has not been biochemically characterized and therefore, its effect on Chek2 protein function is unknown (PubMed, May 2024).
Associated Drug Resistance
Category Variants Paths

CHEK2 mutant CHEK2 P426H

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Transcript NM_007194.4
gDNA chr22:g.28695225G>T
cDNA c.1277C>A
Protein p.P426H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_007194.3 chr22:g.28695225G>T c.1277C>A p.P426H RefSeq GRCh38/hg38
NM_007194.4 chr22:g.28695225G>T c.1277C>A p.P426H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References