Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Gene | ROS1 |
| Variant | Q1797H |
| Impact List | missense |
| Protein Effect | unknown |
| Gene Variant Descriptions | ROS1 Q1797H lies within fibronectin type-III domain 9 of the Ros1 protein (UniProt.org). Q1797H has been identified in sequencing studies (PMID: 30981987), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Sep 2025). |
| Associated Drug Resistance | |
| Category Variants Paths |
ROS1 mutant ROS1 Q1797H |
| Transcript | NM_002944.3 |
| gDNA | chr6:g.117326390C>A |
| cDNA | c.5391G>T |
| Protein | p.Q1797H |
| Source Database | RefSeq |
| Genome Build | GRCh38/hg38 |
| Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
|---|---|---|---|---|---|
| NM_002944.2 | chr6:g.117326390C>A | c.5391G>T | p.Q1797H | RefSeq | GRCh38/hg38 |
| NM_002944 | chr6:g.117326390C>A | c.5391G>T | p.Q1797H | RefSeq | GRCh38/hg38 |
| NM_002944.3 | chr6:g.117326390C>A | c.5391G>T | p.Q1797H | RefSeq | GRCh38/hg38 |
| Molecular Profile | Protein Effect | Treatment Approaches |
|---|---|---|
| ROS1 Q1797H | unknown |