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Gene PIK3CA
Variant C905S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA C905S lies within the PI3K/PI4K domain of the Pik3ca protein (UniProt.org). C905S results in increased levels of cell migration but similar levels of cell proliferation and phosphorylation of Akt to wild-type Pik3ca and is not transforming in culture (PMID: 34779417), and therefore, its effect on Pik3ca protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA C905S

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Transcript NM_006218.4
gDNA chr3:g.179230050T>A
cDNA c.2713T>A
Protein p.C905S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.4 chr3:g.179230050T>A c.2713T>A p.C905S RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179230050T>A c.2713T>A p.C905S RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179230050T>A c.2713T>A p.C905S RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179230050T>A c.2713T>A p.C905S RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179230050T>A c.2713T>A p.C905S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
PIK3CA C905S unknown