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Gene PIK3CA
Variant R335G
Impact List missense
Protein Effect no effect
Gene Variant Descriptions PIK3CA R335G lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). R335G results in levels of cell proliferation, migration, and phosphorylation of Akt similar to wild-type Pik3ca and is not transforming in culture (PMID: 34779417).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon5 PIK3CA R335G

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Transcript NM_006218.4
gDNA chr3:g.179203733A>G
cDNA c.1003A>G
Protein p.R335G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.3 chr3:g.179203733A>G c.1003A>G p.R335G RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179203733A>G c.1003A>G p.R335G RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179203733A>G c.1003A>G p.R335G RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179203733A>G c.1003A>G p.R335G RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179203733A>G c.1003A>G p.R335G RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References