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Gene PIK3CA
Variant R519G
Impact List missense
Protein Effect no effect
Gene Variant Descriptions PIK3CA R519G lies within the PIK helical domain of the Pik3ca protein (UniProt.org). R519G results in levels of cell proliferation, migration, and phosphorylation of Akt similar to wild-type Pik3ca and is not transforming in culture (PMID: 34779417).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon10 PIK3CA R519G

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Transcript NM_006218.4
gDNA chr3:g.179218225A>G
cDNA c.1555A>G
Protein p.R519G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894.2 chr3:g.179218225A>G c.1555A>G p.R519G RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179218225A>G c.1555A>G p.R519G RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179218225A>G c.1555A>G p.R519G RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179218225A>G c.1555A>G p.R519G RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179218225A>G c.1555A>G p.R519G RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
PIK3CA R519G no effect